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Ibiglustat succinate

Name: Ibiglustat succinate
Brand: TargetMol
SKU: T39105
Price: 39 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T39105Cas No. 1629063-80-4

Alias Venglustat succinate, SAR402671succinate, Ibiglustat succinate, GZ402671succinate

Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS) utilized in the investigation of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.

Ibiglustat succinate

🥰Excellent

Catalog No. T39105Alias Venglustat succinate, SAR402671succinate, Ibiglustat succinate, GZ402671succinateCas No. 1629063-80-4

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Product Introduction

Bioactivity

Description	Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS) utilized in the investigation of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
In vitro	Ibiglustat succinate (SAR402671) administered at 1 μM for 15 days to Fabry disease (FD) cells results in GL-3 levels nearly equivalent to those in untreated wild-type (WT) cells, indicating its potential to halt further GL-3 accumulation and mitigate excessive sphingolipid levels in FD cardiomyocytes[4].
Alias	Venglustat succinate, SAR402671succinate, Ibiglustat succinate, GZ402671succinate

Chemical Properties

Molecular Weight	507.58
Formula	C₂₄H₃₀FN₃O₆S
Cas No.	1629063-80-4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ibiglustat SuccinateVenglustat Succinate