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Pack Size | Price | Availability | Quantity |
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100 mg | Inquiry | Backorder | |
500 mg | Inquiry | Backorder |
Description | Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, has an IC50 of 0.755-1.02 nM for BTK. |
In vitro | Ibrutinib-biotin (Compound 1-5) is a probe composed of Ibrutinib, a TEC family kinase inhibitor, connected to biotin through a long-chain linker. The TEC family includes five kinases: TEC, BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX, and TXK/RLK, which are involved in phosphotyrosine- and phospholipid-mediated signaling pathways. These kinases, notably prevalent in hematopoietic tissues, are crucial for the proliferation and differentiation of blood cells[1]. |
Molecular Weight | 1097.39 |
Formula | C56H80N12O9S |
Cas No. | 1599432-18-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (45.56 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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