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Ibrutinib-biotin

Name: Ibrutinib-biotin
Brand: TargetMol
SKU: T18049
Price: 30 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T18049Cas No. 1599432-18-4

Ibrutinib-biotin, a probe consisting of Ibrutinib linked to biotin via a long-chain linker, has an IC50 of 0.755-1.02 nM for BTK.

Ibrutinib-biotin

😃Good

Catalog No. T18049Cas No. 1599432-18-4

Ibrutinib-biotin, a probe consisting of Ibrutinib linked to biotin via a long-chain linker, has an IC50 of 0.755-1.02 nM for BTK.

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Product Introduction

Bioactivity

Description	Ibrutinib-biotin, a probe consisting of Ibrutinib linked to biotin via a long-chain linker, has an IC50 of 0.755-1.02 nM for BTK.
Targets&IC50	BLK:3.66-4.27 nM (IC50), JAK3:5.34-4.87 μM (IC50), BMX:4.42-5.57 nM (IC50), ITK:0.187-0.198 μM (IC50), TEC:1.71-2.29 nM (IC50), BTK:0.755-1.02 nM (IC50), Lck:5.99-6.92 nM (IC50), Src:33.8-36.3 nM (IC50)
In vitro	Ibrutinib-biotin (Compound 1-5) is a probe composed of Ibrutinib, a TEC family kinase inhibitor, connected to biotin through a long-chain linker. The TEC family includes five kinases: TEC, BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX, and TXK/RLK, which are involved in phosphotyrosine- and phospholipid-mediated signaling pathways. These kinases, notably prevalent in hematopoietic tissues, are crucial for the proliferation and differentiation of blood cells[1].

Chemical Properties

Molecular Weight	1097.39
Formula	C₅₆H₈₀N₁₂O₉S
Cas No.	1599432-18-4
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (45.56 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9113 mL	4.5563 mL	9.1125 mL	45.5627 mL
5 mM	0.1823 mL	0.9113 mL	1.8225 mL	9.1125 mL
10 mM	0.0911 mL	0.4556 mL	0.9113 mL	4.5563 mL
20 mM	0.0456 mL	0.2278 mL	0.4556 mL	2.2781 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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