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Icotrokinra

Name: Icotrokinra
Brand: TargetMol
SKU: T89073
Price: 29 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T89073Cas No. 2763602-16-8

Alias PN-235, JNJ-77242113, JNJ-2113

Icotrokinra (JNJ-77242113) is an orally effective selective antagonist of the IL-23 receptor (IL-23 receptor), demonstrating high affinity with a dissociation constant (Kd) of 7.1 pM for the human IL-23 receptor (hIL-23R). It inhibits IL-23-induced STAT3 phosphorylation in PBMC with an IC50 of 5.6 pM and suppresses the production of IFNγ and IL-17A at the epidermal level induced by IL-23. Additionally, Icotrokinra exhibits anti-inflammatory activity in a rat model of TNBS-induced colitis.

Icotrokinra

Catalog No. T89073Alias PN-235, JNJ-77242113, JNJ-2113Cas No. 2763602-16-8

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50 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	Icotrokinra (JNJ-77242113) is an orally effective selective antagonist of the IL-23 receptor (IL-23 receptor), demonstrating high affinity with a dissociation constant (Kd) of 7.1 pM for the human IL-23 receptor (hIL-23R). It inhibits IL-23-induced STAT3 phosphorylation in PBMC with an IC50 of 5.6 pM and suppresses the production of IFNγ and IL-17A at the epidermal level induced by IL-23. Additionally, Icotrokinra exhibits anti-inflammatory activity in a rat model of TNBS-induced colitis.
Targets&IC50	IL-23:7.1 pM (Kd)
Alias	PN-235, JNJ-77242113, JNJ-2113

Chemical Properties

Molecular Weight	1898.17
Formula	C₉₀H₁₂₀N₂₀O₂₂S₂
Cas No.	2763602-16-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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