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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $297 | In Stock | |
5 mg | $788 | In Stock | |
10 mg | $1,230 | In Stock |
Description | Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2. |
Targets&IC50 | Hematologic cancer cells:0.05-65 ng/mL |
In vitro | Idactamab exhibits inhibitory effects on various hematologic cancer cell lines, with an IC50 ranging from 0.05 to 65 ng/mL [2]. ASCT2 (SLC1A5) is a multi-channel, Na+-dependent neutral amino acid transporter that mediates the uptake of amino acids required for tumor growth and progression [2]. |
In vivo | Idactamab enhances the survival rates of three disseminated acute myeloid leukemia (AML) cell line models: TF1α (high expression of ASCT2), MOLM-13 (low expression of ASCT2), and M.V.411 (high expression of ASCT2). The corresponding minimum inhibitory concentrations are 0.05 mg/kg, 0.1 mg/kg, and 0.1 mg/kg, respectively [1]. |
Alias | INT-001 |
Cas No. | 2245205-37-0 |
Storage | store at low temperature | store at -80°C | Shipping with blue ice. |
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