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IDO1/TDO-IN-4
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Catalog No. T60318Cas No. 461424-21-5
IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO. IDO1/TDO-IN-4 rescues lipopolysaccharide-induced depressive-like behaviors in mice, used for cancer and Alzheimer's disease research.
IDO1/TDO-IN-4
😃Good
Catalog No. T60318Cas No. 461424-21-5
IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO. IDO1/TDO-IN-4 rescues lipopolysaccharide-induced depressive-like behaviors in mice, used for cancer and Alzheimer's disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $59 | In Stock | |
| 5 mg | $128 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO. IDO1/TDO-IN-4 rescues lipopolysaccharide-induced depressive-like behaviors in mice, used for cancer and Alzheimer's disease research. |
| Targets&IC50 | TDO:1.15 μM, IDO1:3.53 μM |
| In vitro | IDO1/TDO-IN-4 has dual inhibition on IDO1 and TDO with IC50 values of 3.53 μM and 1.15 μM, respectively. IDO1/TDO-IN-4 (0-2 μM, 1 h) can inhibit the activity of BV2 microglia induced by LPS. [1] |
| In vivo | IDO1/TDO-IN-4 (20 mg/kg) also salvaged lipopolysaccharids-induced depression-like behavior IN mice. [1] |
| Molecular Weight | 234.26 |
| Formula | C14H10N4 |
| Cas No. | 461424-21-5 |
| Smiles | N1=CNC(=C1)C=2N=CC=C3C4=CC=CC=C4NC23 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (426.88 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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