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BMS-986242

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Purity:98.25%

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COA HNMR HPLC

BMS-986242

Catalog No. T9164Cas No. 1923844-48-7

BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.

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Pack Size	Price	Availability
1 mg	$175	In Stock
5 mg	$372	In Stock
10 mg	$556	In Stock
25 mg	$896	In Stock
50 mg	$1,220	In Stock
100 mg	$1,650	In Stock
1 mL x 10 mM (in DMSO)	$397	In Stock

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Product Introduction

Bioactivity

Description	BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
In vitro	BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 exhibts IC50>25 μM for all targets except nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50>6 μM with ～20 % max inhibition).
In vivo	BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) shows dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses
Alias	BMS986242

Chemical Properties

Molecular Weight	410.91
Formula	C24H24ClFN2O
Cas No.	1923844-48-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (608.41 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4336 mL	12.1681 mL	24.3362 mL	121.6811 mL
5 mM	0.4867 mL	2.4336 mL	4.8672 mL	24.3362 mL
10 mM	0.2434 mL	1.2168 mL	2.4336 mL	12.1681 mL
20 mM	0.1217 mL	0.6084 mL	1.2168 mL	6.0841 mL
50 mM	0.0487 mL	0.2434 mL	0.4867 mL	2.4336 mL
100 mM	0.0243 mL	0.1217 mL	0.2434 mL	1.2168 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc