Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA) is the R enantiomer of (Rac)-Idroxioleic acid. It is an orally active fatty acid recognized for its capacity to modulate lipid composition and membrane structure. With demonstrated antitumor activities, Idroxioleic acid is significant in cancer research.

(R)-2-Hydroxyoleic acid ((R)-2-OHOA), also known as idroxioleic acid, effectively inhibited the growth of the A549 lung adenocarcinoma cell line, demonstrating an IC50 value of 252 μM[1].

(R)-2-Hydroxyoleic acid (R)-2-OHOA, administered orally at a dosage of 400 mg/kg daily for 21 days, led to a 20-25% decrease in tumor volume[1]. This outcome was observed in a study involving male NUDE (Swiss) Crl:NU(Ico)-Foxn1nu mice, aged 5 weeks and weighing 30-35 g, which were injected with A549 human lung cancer cells[1].