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IDT307

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Catalog No. T38516Cas No. 1141-41-9
Alias IDT 307

IDT307 is a fluorescent analog of MPP+, a fluorescent substrate for DAT (fluorescent substrate APP+), and can be used for rapid identification and characterization of PMAT inhibitors.

IDT307

IDT307

🥰Excellent
Catalog No. T38516Alias IDT 307Cas No. 1141-41-9
IDT307 is a fluorescent analog of MPP+, a fluorescent substrate for DAT (fluorescent substrate APP+), and can be used for rapid identification and characterization of PMAT inhibitors.
Pack SizePriceAvailabilityQuantity
2 mg$36In Stock
5 mg$64In Stock
1 mL x 10 mM (in DMSO)$54In Stock
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Product Introduction

Bioactivity
Description
IDT307 is a fluorescent analog of MPP+, a fluorescent substrate for DAT (fluorescent substrate APP+), and can be used for rapid identification and characterization of PMAT inhibitors.
In vitro
IDT307 is an analog of the organic cation MPP+, which is transported to the parietal membrane (cerebrospinal fluid-facing side) of choroid plexus (CP) epithelial cells. Its transport process is highly sensitive to the PMAT inhibitor quinine. In Pmat knockout mice, uptake of IDT307 by choroid plexus tissue and its intracellular accumulation are significantly reduced by approximately 70%. [1]
AliasIDT 307
Chemical Properties
Molecular Weight340.2
FormulaC14H17IN2
Cas No.1141-41-9
Smiles[I-].C=1C=C(C=CC1C=2C=C[N+](=CC2)C)N(C)C
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50.00 mg/mL (146.97 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9394 mL14.6972 mL29.3945 mL146.9724 mL
5 mM0.5879 mL2.9394 mL5.8789 mL29.3945 mL
10 mM0.2939 mL1.4697 mL2.9394 mL14.6972 mL
20 mM0.1470 mL0.7349 mL1.4697 mL7.3486 mL
50 mM0.0588 mL0.2939 mL0.5879 mL2.9394 mL
100 mM0.0294 mL0.1470 mL0.2939 mL1.4697 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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