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Imidaprilate
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Catalog No. T11642Cas No. 89371-44-8
Alias Imidaprilat, 6366A
Imidaprilate, an active metabolite of TA-6366, is a potent angiotensin-converting enzyme (ACE) inhibitor (IC50: 2.6 nM) used in hypertension research.
Imidaprilate
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Catalog No. T11642Alias Imidaprilat, 6366ACas No. 89371-44-8
Imidaprilate, an active metabolite of TA-6366, is a potent angiotensin-converting enzyme (ACE) inhibitor (IC50: 2.6 nM) used in hypertension research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $398 | 35 days | |
| 1 mg | $715 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Imidaprilate, an active metabolite of TA-6366, is a potent angiotensin-converting enzyme (ACE) inhibitor (IC50: 2.6 nM) used in hypertension research. |
| Targets&IC50 | ACE:2.6 nM |
| In vitro | Imidaprilate augments the bradykinin-induced contraction of guinea pig ileum, with AC50 of 1.7 nM.Imidaprilate ?is an active metabolite of 6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM. |
| In vivo | Imidaprilate (≥0.2 mg/kg) inhibits the pressor response induced by angiotensin I (AT-I). |
| Alias | Imidaprilat, 6366A |
| Molecular Weight | 377.39 |
| Formula | C18H23N3O6 |
| Cas No. | 89371-44-8 |
| Relative Density. | 1.356 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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