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IMMU-114

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Catalog No. T77435
Alias IMMU114, hL243

IMMU-114 is a humanized antibody targeting HLA-DR, which inhibits human responses to bovine cells, used in malignant tumor research.

IMMU-114

IMMU-114

🥰Excellent
Catalog No. T77435Alias IMMU114, hL243
IMMU-114 is a humanized antibody targeting HLA-DR, which inhibits human responses to bovine cells, used in malignant tumor research.
Pack SizePriceAvailabilityQuantity
1 mg$447 In Stock
5 mg$1,400 In Stock
10 mg$2,240 In Stock
25 mg$4,210 In Stock
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Concentration:7.35 mg/mL
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Product Introduction

Bioactivity
Description
IMMU-114 is a humanized antibody targeting HLA-DR, which inhibits human responses to bovine cells, used in malignant tumor research.
In vitro
IMMU-114 can effectively inhibit human cell response to cattle. The mechanism involves direct inhibition of interactions between Class II human leukocyte antigen DR Positive cells and CD4 (+) T cells, as well as indirect inhibition of Th1 cytokine production. [1]
In allogeneic MLRs, IMMU-114 treatment inhibited T cell proliferation and reduced CD25 (+) alloreactive T cells. [2]
In vivo
In seven human disease models (acute lymphoblastic leukemia (ALL), chronic lymphoblastic leukemia (CLL), multiple myeloma (MM), acute myeloid leukemia (AML), diffuse large B-cell lymphoma (DLBCL), Hodgkin lymphoma (HL), and melanoma), IMMU-114 has anti-tumor effect. [3]
AliasIMMU114, hL243
Chemical Properties
Molecular Weight145.5
Smiles#N/A
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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