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IMMU-114 is a humanized antibody targeting HLA-DR, which inhibits human responses to bovine cells, used in malignant tumor research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $447 | In Stock | |
5 mg | $1,400 | In Stock | |
10 mg | $2,240 | In Stock | |
25 mg | $4,210 | In Stock |
Description | IMMU-114 is a humanized antibody targeting HLA-DR, which inhibits human responses to bovine cells, used in malignant tumor research. |
In vitro | IMMU-114 can effectively inhibit human cell response to cattle. The mechanism involves direct inhibition of interactions between Class II human leukocyte antigen DR Positive cells and CD4 (+) T cells, as well as indirect inhibition of Th1 cytokine production. [1] In allogeneic MLRs, IMMU-114 treatment inhibited T cell proliferation and reduced CD25 (+) alloreactive T cells. [2] |
In vivo | In seven human disease models (acute lymphoblastic leukemia (ALL), chronic lymphoblastic leukemia (CLL), multiple myeloma (MM), acute myeloid leukemia (AML), diffuse large B-cell lymphoma (DLBCL), Hodgkin lymphoma (HL), and melanoma), IMMU-114 has anti-tumor effect. [3] |
Alias | IMMU114, hL243 |
Molecular Weight | 145.5 |
Smiles | #N/A |
Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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