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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $970 | Backorder |
Description | INCB059872 is a highly potent, orally active, selective, and irreversible inhibitor of Lysine-Specific Demethylase 1 (LSD1). Its chemical properties make it suitable for use in researching myeloid leukemia. |
In vitro | INCB059872 (25 nM; 48 hours; 293T cells) increases enhancer activity and gene expression[1]. INCB059872 (25 nM; 24 hours; THP-1 cells) makes THP-1 show a growth defect within one cell doubling time or approximately 3 days. INCB059872 (100 nM; 24 hours; MV-4–11 cells) treated MV-4–11 cells continues to grow as DMSO-treated cells for multiple cell divisions. INCB059872 (THP-1 cells) regulates PRO-seq analysis identifies genes and enhancers[1]. Western Blot Analysis[1]Cell Line: 293T cells Concentration: 250 nM Incubation Time: 48 hours Result: Increased enhancer activity and gene expression. |
In vivo | INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 days) administration in mice resulted in alterations in bone marrow progenitor populations, as identified by single-cell RNA sequencing[1]. |
Alias | INCB059872 |
Molecular Weight | 386.536 |
Formula | C23H34N2O3 |
Cas No. | 1802909-49-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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