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Description | IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM and impeding IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. It also effectively inhibits the splicing of XBP1 mRNA in wild-type cell lines. |
In vitro | IRE1α kinase-IN-2 (compound 3) inhibits XBP1 mRNA splicing, even under ER stress[1]. |
Alias | IRE1α kinase-IN-2 |
Molecular Weight | 504.517 |
Formula | C27H23F3N6O |
Cas No. | 1414938-21-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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