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IRE1α kinase-IN-2

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IRE1α kinase-IN-2

Catalog No. T38841Cas No. 1414938-21-8

IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM and impeding IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. It also effectively inhibits the splicing of XBP1 mRNA in wild-type cell lines.

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Product Introduction

Bioactivity

Description	IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM and impeding IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. It also effectively inhibits the splicing of XBP1 mRNA in wild-type cell lines.
In vitro	IRE1α kinase-IN-2 (compound 3) inhibits XBP1 mRNA splicing, even under ER stress[1].
Alias	IRE1α kinase-IN-2

Chemical Properties

Molecular Weight	504.517
Formula	C27H23F3N6O
Cas No.	1414938-21-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

IRE1α kinaseIN2IRE1α kinase IN 2IRE1alpha kinase-IN-2IRE-1α kinase-IN-2IRE1a kinase-IN-2