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IRE1α kinase-IN-2

🥰Excellent
Catalog No. T38841Cas No. 1414938-21-8
Alias IRE1α kinase-IN-2

IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM and impeding IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. It also effectively inhibits the splicing of XBP1 mRNA in wild-type cell lines.

IRE1α kinase-IN-2

IRE1α kinase-IN-2

🥰Excellent
Catalog No. T38841Alias IRE1α kinase-IN-2Cas No. 1414938-21-8
IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM and impeding IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. It also effectively inhibits the splicing of XBP1 mRNA in wild-type cell lines.
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Product Introduction

Bioactivity
Description
IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM and impeding IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. It also effectively inhibits the splicing of XBP1 mRNA in wild-type cell lines.
In vitro
IRE1α kinase-IN-2 (compound 3) inhibits XBP1 mRNA splicing, even under ER stress[1].
AliasIRE1α kinase-IN-2
Chemical Properties
Molecular Weight504.517
FormulaC27H23F3N6O
Cas No.1414938-21-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

IRE1α kinaseIN2IRE1α kinase IN 2IRE1alpha kinase-IN-2IRE-1α kinase-IN-2IRE1a kinase-IN-2
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