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Isoformononetin
🥰Excellent
Catalog No. TN1778Cas No. 486-63-5
Alias Dehydroevodiamine, 4''-Hydroxy-7-Methoxyisoflavone
Isoformononetin (IFN) is a methoxy isoflavone present in human dietary supplements that exhibits immune-protective effects by preventing neuroinflammation in a streptozotocin-induced rat model through inhibition of the NLRP3/ASC/IL-1 axis activation.
Isoformononetin
🥰Excellent
Catalog No. TN1778Alias Dehydroevodiamine, 4''-Hydroxy-7-MethoxyisoflavoneCas No. 486-63-5
Isoformononetin (IFN) is a methoxy isoflavone present in human dietary supplements that exhibits immune-protective effects by preventing neuroinflammation in a streptozotocin-induced rat model through inhibition of the NLRP3/ASC/IL-1 axis activation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $206 | In Stock | |
| 5 mg | $515 | In Stock | |
| 10 mg | $820 | In Stock | |
| 25 mg | $1,476 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Isoformononetin (IFN) is a methoxy isoflavone present in human dietary supplements that exhibits immune-protective effects by preventing neuroinflammation in a streptozotocin-induced rat model through inhibition of the NLRP3/ASC/IL-1 axis activation. |
| In vitro | Isoformononetinn (10-8 M) promotes differentiation of osteoblasts involved in activation of the MEK-Erk and Akt pathways and exhibits potent anti-apoptotic effects. [2] |
| In vivo | Isoformononetin was administered orally at a dose of 10mg/kg once a day for 21 days, and the results showed that Isoformononetin was neuroprotective against STZ-induced inflammation. [1] Isoformononetin (10.0 mg/kg/ day) tube feeding can increase the bone mineral density (BMD) of bone site and promote the growth and development of uterus in SD rats. [2] |
| Alias | Dehydroevodiamine, 4''-Hydroxy-7-Methoxyisoflavone |
| Molecular Weight | 268.26 |
| Formula | C16H12O4 |
| Cas No. | 486-63-5 |
| Smiles | O=C1C(=COC2=CC(OC)=CC=C21)C=3C=CC(O)=CC3 |
| Relative Density. | 1.329 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200.00 mg/mL (745.55 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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