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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $1,450 | 10-14 weeks | |
25 mg | $2,980 | 10-14 weeks |
Description | Ivaltinostat (CG-200745) formic is an oral active panHDAC inhibitor with an isohydroxamic acid component that binds zinc at the bottom of the catalytic pocket. Ivaltinostat formic inhibited the deacetylation of histone H3 and tubulin. Ivaltinostat formic promotes p53 accumulation, induces p53-dependent trans activation, and enhances MDM2 and p21 (Waf1/Cip1) protein expression. Ivaltinostat formic increases the sensitivity of Gemcitabine resistant cells to Gemcitabine and 5-Fluorouracil (5-FU). Ivaltinostat formic induces apoptosis and has antitumor effect. |
Molecular Weight | 473.56 |
Formula | C25H35N3O6 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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