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J-104132

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J-104132

Catalog No. T27647Cas No. 198279-45-7

J-104132 is a potetn and selective endothelin A/B receptor antagonist (Ki: cloned human ETA = 0.034 nM; cloned human ETB = 0.104 nM) . In vitro, J-104132 is a potent antagonist of ET-1-induced accumulation of [3H]inositol phosphates in Chinese hamster ovary cells stably expressing cloned human ETA receptors (IC50 = 0.059 nM). Pretreatment with J-104132 prevents the lethal response to ET-1 when administered i.v. (ED50 = 0.045 mg/kg) or p.o. in fed animals (ED50 = 0.35 mg/kg).

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Pack Size	Price	Availability
25 mg	$4,370	10-14 weeks
50 mg	$5,780	10-14 weeks
100 mg	$8,200	10-14 weeks

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Product Introduction

Bioactivity

Description	J-104132 is a potetn and selective endothelin A/B receptor antagonist (Ki: cloned human ETA = 0.034 nM; cloned human ETB = 0.104 nM) . In vitro, J-104132 is a potent antagonist of ET-1-induced accumulation of [3H]inositol phosphates in Chinese hamster ova
Alias	L753037, L 753037, J104132, J 104132, L-753037

Chemical Properties

Molecular Weight	531.6
Formula	C31H33NO7
Cas No.	198279-45-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

J-104132