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JPS014

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Catalog No. T74453Cas No. 2669785-76-4

JPS014, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), exhibiting potency as an HDAC1/2 degrader. This correlation is associated with an increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].

JPS014
Other Forms of JPS014:
JPS014 TFAT77937
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JPS014

😃Good
Catalog No. T74453Cas No. 2669785-76-4
JPS014, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), exhibiting potency as an HDAC1/2 degrader. This correlation is associated with an increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].
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Product Introduction

Bioactivity
Description
JPS014, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), exhibiting potency as an HDAC1/2 degrader. This correlation is associated with an increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].
Chemical Properties
Molecular Weight854.07
FormulaC46H59N7O7S
Cas No.2669785-76-4
Storage & Solubility Information
StorageShipping with blue ice.

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