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K-Ras ligand-Linker Conjugate 3

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Catalog No. T18056Cas No. 2378261-87-9

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound comprising a ligand for the K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential for synthesizing PROTAC K-Ras Degrader-1, a potent degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 3

K-Ras ligand-Linker Conjugate 3

😃Good
Catalog No. T18056Cas No. 2378261-87-9
K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound comprising a ligand for the K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential for synthesizing PROTAC K-Ras Degrader-1, a potent degrader with a degradation efficacy of ≥70% in SW1573 cells[1].
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Product Introduction

Bioactivity
Description
K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound comprising a ligand for the K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential for synthesizing PROTAC K-Ras Degrader-1, a potent degrader with a degradation efficacy of ≥70% in SW1573 cells[1].
In vitro
PROTACs consist of two ligands linked together: one binds to an E3 ubiquitin ligase and the other binds to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Chemical Properties
Molecular Weight944.15
FormulaC49H65N7O10S
Cas No.2378261-87-9
Relative Density.1.32 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

K-Ras ligand-Linker Conjugate 3K Ras ligand Linker Conjugate 3KRas ligandLinker Conjugate 3
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