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Signaling PathwaysOthers-PROTACOthers-Target Protein Ligand-Linker ConjugateK-Ras ligand-Linker Conjugate 5
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K-Ras ligand-Linker Conjugate 5

K-Ras ligand-Linker Conjugate 5
K-Ras ligand-Linker Conjugate 5 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker for E3 ligases, such as VHL, CRBN, MDM2, and IAP. This conjugate is crucial for synthesizing PROTAC K-Ras Degrader-1, displaying a degradation efficacy of ≥70% in SW1573 cells [1].
Catalog No. T18058Cas No. 2378261-85-7
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K-Ras ligand-Linker Conjugate 5

Catalog No. T18058Cas No. 2378261-85-7
K-Ras ligand-Linker Conjugate 5 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker for E3 ligases, such as VHL, CRBN, MDM2, and IAP. This conjugate is crucial for synthesizing PROTAC K-Ras Degrader-1, displaying a degradation efficacy of ≥70% in SW1573 cells [1].
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2 mg$855 days
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Product Introduction

Bioactivity
Description
K-Ras ligand-Linker Conjugate 5 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker for E3 ligases, such as VHL, CRBN, MDM2, and IAP. This conjugate is crucial for synthesizing PROTAC K-Ras Degrader-1, displaying a degradation efficacy of ≥70% in SW1573 cells [1].
In vitro
PROTACs consist of two distinct ligands linked together, with one ligand targeting an E3 ubiquitin ligase and the other targeting a specific protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Chemical Properties
Molecular Weight789.96
FormulaC42H59N7O8
Cas No.2378261-85-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

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