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K-Ras ligand-Linker Conjugate 6

Name: K-Ras ligand-Linker Conjugate 6
Brand: TargetMol
SKU: T18059
Price: 124 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18059Cas No. 2378261-89-1

K-Ras ligand-Linker Conjugate 6 is a compound that combines a K-Ras-recruiting fragment ligand and a PROTAC linker to recruit E3 ligase for the synthesis of PROTAC K-Ras Degrader-1.

K-Ras ligand-Linker Conjugate 6

🥰Excellent

Catalog No. T18059Cas No. 2378261-89-1

K-Ras ligand-Linker Conjugate 6 is a compound that combines a K-Ras-recruiting fragment ligand and a PROTAC linker to recruit E3 ligase for the synthesis of PROTAC K-Ras Degrader-1.

Pack Size	Price	Availability	Quantity
2 mg	$124	In Stock

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Product Introduction

Bioactivity

Description

K-Ras ligand-Linker Conjugate 6 is a compound that combines a K-Ras-recruiting fragment ligand and a PROTAC linker to recruit E3 ligase for the synthesis of PROTAC K-Ras Degrader-1.

Chemical Properties

Molecular Weight	788.98
Formula	C₄₂H₆₀N₈O₇
Cas No.	2378261-89-1
Smiles	O(C[C@@H]1C[C@@H](OCCOCCOCCOCCN)CN1C)C2=NC(=C3C(CN(CC3)C=4C5=C(C=CC4)C=CC=C5)=N2)N6C[C@H](CC#N)N(C(OC(C)(C)C)=O)CC6
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 40 mg/mL (50.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2675 mL	6.3373 mL	12.6746 mL	63.3730 mL
5 mM	0.2535 mL	1.2675 mL	2.5349 mL	12.6746 mL
10 mM	0.1267 mL	0.6337 mL	1.2675 mL	6.3373 mL
20 mM	0.0634 mL	0.3169 mL	0.6337 mL	3.1686 mL
50 mM	0.0253 mL	0.1267 mL	0.2535 mL	1.2675 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

K-Ras ligand-Linker Conjugate 6KRas ligandLinker Conjugate 6K Ras ligand Linker Conjugate 6

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