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Kanglexin

Name: Kanglexin
Brand: TargetMol
SKU: T203479
Rating: 4.5 (1 reviews)

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Catalog No. T203479Cas No. 2228847-12-7

Kanglexin is an orally active novel anthraquinone compound. It inhibits NLRP3 inflammasome activation and pyroptosis, offering cardioprotective benefits. By stimulating the FGFR1/ERK signaling pathway, Kanglexin promotes angiogenesis and accelerates wound healing in diabetes. Additionally, it has lipid-lowering effects and inhibits vascular smooth muscle cell dedifferentiation, making it a potential compound for studying hyperlipidemia, fatty liver, and atherosclerosis.

Kanglexin

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Catalog No. T203479Cas No. 2228847-12-7

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description	Kanglexin is an orally active novel anthraquinone compound. It inhibits NLRP3 inflammasome activation and pyroptosis, offering cardioprotective benefits. By stimulating the FGFR1/ERK signaling pathway, Kanglexin promotes angiogenesis and accelerates wound healing in diabetes. Additionally, it has lipid-lowering effects and inhibits vascular smooth muscle cell dedifferentiation, making it a potential compound for studying hyperlipidemia, fatty liver, and atherosclerosis.
In vitro	Kanglexin (10-20 μM; 24 hours) inhibits pyroptosis in cardiomyocytes treated with hypoxia or LPS. Additionally, Kanglexin (5-20 μM; 24 hours) reduces lipid levels in oleic acid-treated HepG2 cells via the AMPK/SREBP-2/PCSK9/LDLR signaling pathway.
In vivo	Kanglexin (20-40 mg/kg; gavage; 7 days) demonstrates beneficial effects in a mouse model of myocardial infarction. Additionally, Kanglexin (20-80 mg/kg; oral; 2 weeks) shows improvements in a rat model of hyperlipidemia.

Chemical Properties

Molecular Weight	398.36
Formula	C₂₁H₁₈O₈
Cas No.	2228847-12-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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