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KOTX1 is an orally active and selective inhibitor of ALDH1A3. In a diabetic mouse model, KOTX1 improves glucose tolerance, insulin secretion, and blood glucose levels.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | KOTX1 is an orally active and selective inhibitor of ALDH1A3. In a diabetic mouse model, KOTX1 improves glucose tolerance, insulin secretion, and blood glucose levels. |
In vitro | KOTX1 (0-1 μM) demonstrates an IC 50 of 5.14 nM for ALDH1A3 in A375 cells. |
In vivo | KOTX1 (40 mg/kg; administered orally; 4 weeks) shows beneficial effects in a diabetic mouse model. |
Molecular Weight | 313.33 |
Formula | C17H16FN3O2 |
Cas No. | 1788963-83-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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