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KRAS G12C inhibitor 18

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KRAS G12C inhibitor 18

Catalog No. T40285Cas No. 2649788-45-2

KRAS G12C inhibitor 18 is a potent and orally active compound that inhibits KRAS G12C, demonstrating significant anti-tumor activities.

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Pack Size	Price	Availability	Quantity
5 mg	$4,250	Backorder

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Product Introduction

Bioactivity

Description	KRAS G12C inhibitor 18 is a potent and orally active compound that inhibits KRAS G12C, demonstrating significant anti-tumor activities.
In vitro	The compound, KRAS G12C inhibitor 18 (compound 34), effectively suppresses the proliferation of various tumor cell lines harboring the KRas G12C mutation, including H358, SW1436, and MiaPaca-2 cells, among others[1].
In vivo	KRAS G12C inhibitor 18 demonstrates a dose-dependent reduction in pERK and active KRas levels, evident at 8 hours post-administration, with single doses ranging from 12.5 to 100 mg/kg[1]. Additionally, at a dosage of 30 mg/kg administered orally twice daily, it exhibits significant anti-tumor activity in a lung cancer H358 xenograft mouse model[1].

Chemical Properties

Molecular Weight	510.97
Formula	C25H20ClFN4O3S
Cas No.	2649788-45-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KRAS G-12C inhibitor 18KRAS G12C inhibitor 18