Shopping Cart

Remove All
Your shopping cart is currently empty

KRAS G12C inhibitor 18

Name: KRAS G12C inhibitor 18
Brand: TargetMol
SKU: T40285
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T40285Cas No. 2649788-45-2

KRAS G12C inhibitor 18 is a potent and orally active compound that inhibits KRAS G12C, demonstrating significant anti-tumor activities.

KRAS G12C inhibitor 18

😃Good

Catalog No. T40285Cas No. 2649788-45-2

KRAS G12C inhibitor 18 is a potent and orally active compound that inhibits KRAS G12C, demonstrating significant anti-tumor activities.

Pack Size	Price	Availability	Quantity
5 mg	$4,250	Backorder

Bulk & Custom

Add to Cart

Questions

Resource Download

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	KRAS G12C inhibitor 18 is a potent and orally active compound that inhibits KRAS G12C, demonstrating significant anti-tumor activities.
In vitro	The compound, KRAS G12C inhibitor 18 (compound 34), effectively suppresses the proliferation of various tumor cell lines harboring the KRas G12C mutation, including H358, SW1436, and MiaPaca-2 cells, among others[1].
In vivo	KRAS G12C inhibitor 18 demonstrates a dose-dependent reduction in pERK and active KRas levels, evident at 8 hours post-administration, with single doses ranging from 12.5 to 100 mg/kg[1]. Additionally, at a dosage of 30 mg/kg administered orally twice daily, it exhibits significant anti-tumor activity in a lung cancer H358 xenograft mouse model[1].

Chemical Properties

Molecular Weight	510.97
Formula	C₂₅H₂₀ClFN₄O₃S
Cas No.	2649788-45-2
Relative Density.	1.52 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KRAS G-12C inhibitor 18KRAS G12C inhibitor 18