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KRFK TFA, a TSP-1-derived peptide, activates TGF-β and enhances its associated signaling pathways independently of thrombospondin (TSP) receptors like CD47 and CD36. This compound has potential applications in research on chronic ocular surface inflammatory disorders [1].
Description | KRFK TFA, a TSP-1-derived peptide, activates TGF-β and enhances its associated signaling pathways independently of thrombospondin (TSP) receptors like CD47 and CD36. This compound has potential applications in research on chronic ocular surface inflammatory disorders [1]. |
In vitro | KRFK TFA (50 μM; 24 h) stimulates TGF-β secretion and decreases dendritic cell maturation markers in TSP-1-deficient bone marrow-derived dendritic cells (BMDCs) [1]. |
In vivo | KRFK TFA (administered as a single dose of 5 μg/5 µL to one eye) significantly prevented the development of chronic ocular surface inflammation in TSP-1 -/- mice [1]. |
Formula | C27H47N9O5.xC2HF3O2 |
Storage | keep away from moisture | Shipping with blue ice. |
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