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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 1-2 weeks | |
50 mg | $1,980 | 1-2 weeks | |
100 mg | $2,500 | 1-2 weeks |
Description | KRN2 has potential to treat NFAT5-mediated Chronic Arthritis. KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 100 nM. |
In vitro | KRN2 selectively and dose-dependently inhibits the binding of NF-κB p65 to the Nfat5 promoter 1 and impedes its interaction with the DNA binding sequence located in the upstream site (base pairs -3000 to +1) of Nfat5 exon 1. Moreover, KRN2 effectively suppresses the expression of pro-inflammatory genes such as Nos2 and Il6, while sparing the activation of high-salt-induced NFAT5 and related target gene expressions. |
In vivo | KRN2 (3 mg/kg, i.p., daily) effectively suppresses CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration.KRN2 (3 mg/kg, i.p., daily for 2 weeks) effectively suppresses AIA in which innate immune cells play a predominant role. |
Molecular Weight | 479.93 |
Formula | C27H23ClFNO4 |
Cas No. | 248260-75-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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