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KRN2
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Catalog No. T11781Cas No. 248260-75-5
KRN2 has potential to treat NFAT5-mediated Chronic Arthritis. KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 100 nM.
KRN2
😃Good
Catalog No. T11781Cas No. 248260-75-5
KRN2 has potential to treat NFAT5-mediated Chronic Arthritis. KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 100 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 1-2 weeks | |
| 50 mg | $1,980 | 1-2 weeks | |
| 100 mg | $2,500 | 1-2 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | KRN2 has potential to treat NFAT5-mediated Chronic Arthritis. KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 100 nM. |
| Targets&IC50 | NFAT5:100 nM |
| In vitro | KRN2 selectively and dose-dependently inhibits the binding of NF-κB p65 to the Nfat5 promoter 1 and impedes its interaction with the DNA binding sequence located in the upstream site (base pairs -3000 to +1) of Nfat5 exon 1. Moreover, KRN2 effectively suppresses the expression of pro-inflammatory genes such as Nos2 and Il6, while sparing the activation of high-salt-induced NFAT5 and related target gene expressions. |
| In vivo | KRN2 (3 mg/kg, i.p., daily) effectively suppresses CIA and AIA in mice by reducing pro-inflammatory cytokines, autoantibodies, and macrophage infiltration. Additionally, KRN2 (3 mg/kg, i.p., daily for 2 weeks) significantly suppresses AIA, where innate immune cells are predominantly involved. |
| Molecular Weight | 479.93 |
| Formula | C27H23ClFNO4 |
| Cas No. | 248260-75-5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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