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KW-8232

Catalog No. T36762Cas No. 217813-15-5

KW-8232, an orally active anti-osteoporotic agent, reduces the biosynthesis of PGE2[1].

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Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	KW-8232, an orally active anti-osteoporotic agent, reduces the biosynthesis of PGE2[1].
In vitro	KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells[1].KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM )[2].
In vivo	KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production[1].

Chemical Properties

Molecular Weight	705.27
Formula	C37H41ClN4O6S
Cas No.	217813-15-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (177.24 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4179 mL	7.0895 mL	14.1790 mL	70.8948 mL
5 mM	0.2836 mL	1.4179 mL	2.8358 mL	14.1790 mL
10 mM	0.1418 mL	0.7089 mL	1.4179 mL	7.0895 mL
20 mM	0.0709 mL	0.3545 mL	0.7089 mL	3.5447 mL
50 mM	0.0284 mL	0.1418 mL	0.2836 mL	1.4179 mL
100 mM	0.0142 mL	0.0709 mL	0.1418 mL	0.7089 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KW-8232KW 8232KW8232