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KW-8232

Name: KW-8232
Brand: TargetMol
SKU: T36762
Price: 45 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T36762Cas No. 217813-15-5

KW-8232, an orally active anti-osteoporotic agent, reduces the biosynthesis of PGE2 [1].

KW-8232

😃Good

Catalog No. T36762Cas No. 217813-15-5

KW-8232, an orally active anti-osteoporotic agent, reduces the biosynthesis of PGE2 [1].

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	KW-8232, an orally active anti-osteoporotic agent, reduces the biosynthesis of PGE2 [1].
In vitro	KW-8232 is an anti-osteoporotic agent that reduces PGE2 biosynthesis in mouse osteoblastic cells[1] and exhibits anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM)[2].
In vivo	KW-8232 (3, 10, 30 mg/kg, p.o.) significantly increases femoral bone mineral density (BMD) in immobilized rat legs and modulates immobilization-induced abnormal bone turnover. At 30 mg/kg, it markedly reduces urinary calcium excretion, pyridinoline, and deoxypyridinoline—markers of bone resorption—in neurectomized rats. KW-8232's inhibition of bone loss may be linked to decreased prostaglandin (PG)-stimulated bone resorption through regulation of PGE2 production[1].

Chemical Properties

Molecular Weight	705.27
Formula	C₃₇H₄₁ClN₄O₆S
Cas No.	217813-15-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (177.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4179 mL	7.0895 mL	14.1790 mL	70.8948 mL
5 mM	0.2836 mL	1.4179 mL	2.8358 mL	14.1790 mL
10 mM	0.1418 mL	0.7089 mL	1.4179 mL	7.0895 mL
20 mM	0.0709 mL	0.3545 mL	0.7089 mL	3.5447 mL
50 mM	0.0284 mL	0.1418 mL	0.2836 mL	1.4179 mL
100 mM	0.0142 mL	0.0709 mL	0.1418 mL	0.7089 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KW-8232KW 8232KW8232