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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | Backorder | |
500 mg | Inquiry | Backorder |
Description | L-159282 is an orally active and nonpeptide angiotensin II receptor antagonist. It also has anti-hypertensive activity. |
In vivo | L-159282 (3 mg/kg, p.o.) decreases blood pressure to normotensive (< 120 mm Hg) levels without reflex tachycardia, in aortic coarcted (high renin) rats. L-159282 (1 mg/kg, iv) produces 100% inhibition of the AII pressor response and is still active (52%) at 24 h, in the anesthetized chimpanzee. This dose of L-159282 decreases blood pressure to approximately the same level as both losartan (3 mg/kg, p.o.) and enalapril (3 mg/kg, p.o.) in this model[1]. |
Alias | MK 996 |
Molecular Weight | 524.63 |
Formula | C30H28N4O3S |
Cas No. | 157263-00-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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