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L-159282 is an orally active and nonpeptide angiotensin II receptor antagonist. It also has anti-hypertensive activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,650 | 6-8 weeks | |
50 mg | $2,240 | 6-8 weeks | |
100 mg | $2,760 | 6-8 weeks |
Description | L-159282 is an orally active and nonpeptide angiotensin II receptor antagonist. It also has anti-hypertensive activity. |
In vivo | L-159282 (3 mg/kg, p.o.) reduces blood pressure to normotensive (< 120 mm Hg) levels without causing reflex tachycardia in aortic coarcted (high renin) rats. In anesthetized chimpanzees, L-159282 (1 mg/kg, iv) completely inhibits the AII pressor response and remains 52% active at 24 hours, decreasing blood pressure to levels comparable to losartan (3 mg/kg, p.o.) and enalapril (3 mg/kg, p.o.) in this model[1]. |
Alias | MK 996 |
Molecular Weight | 524.63 |
Formula | C30H28N4O3S |
Cas No. | 157263-00-8 |
Relative Density. | 1.31g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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