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L-AP3

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L-AP3

Catalog No. T39830Cas No. 23052-80-4

L-AP3 is a potent antagonist of metabotropic glutamate receptor (mGluR), demonstrating inhibitory effects on D-phosphoserine and L-phosphoserine with IC50 values of 368 μM and 2087 μM, respectively.

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Product Introduction

Bioactivity

Description	L-AP3 is a potent antagonist of metabotropic glutamate receptor (mGluR), demonstrating inhibitory effects on D-phosphoserine and L-phosphoserine with IC50 values of 368 μM and 2087 μM, respectively.
In vitro	L-AP3 exhibits inhibitory effects on D-phosphoserine and L-phosphoserine, with inhibition constants (Kis) of 151 μM and 845 μM, respectively[1]. Furthermore, it demonstrates agonistic behavior by enhancing phospholipase D activity and reducing cAMP formation in the rat hippocampus[1]. Its selectivity for Group II subtypes is indicated by its inhibition of [3H]glutamate binding to mGlu3 receptors, with a Ki of 125 μM[1]. Additionally, L-AP3 effectively inhibits sodium-dependent L-[3H]glutamate uptake in both cerebellar and cortical synaptosomes, showing potencies of 39 μM and 110 μM, respectively[1].
In vivo	L-AP3 exhibits anticonvulsant properties, effectively inhibiting audiogenic seizures in DBA/2 mice[1].
Alias	3-Phosphono-L-alanine, L-AP3

Chemical Properties

Molecular Weight	169.073
Formula	C3H8NO5P
Cas No.	23052-80-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

LAP3L-AP-3L AP3