L-Diguluronic acid, a linear polysaccharide copolymer consisting of two L-guluronic acid (G) units, serves as a precursor for Alginate[1], a categorically unbranched polyanionic polysaccharide. Alginate finds application in the development of antifungal agent delivery carriers[2].

Alginate is a term for a group of polyanionic polysaccharides composed of β-d-mannuronic acid (M) and α-l-guluronic acid (G), linked by 1→4 linkages, and characterized by MMM and GGG homosequences interspersed with MGM heterosequences[1].

Alginate is widely used for obtainment of drug delivery systems due to its non-toxicity, biodegradability, biocompatibility, mucoadhesive, and non-immunogenic properties. Additionally, alginate-based antifungal delivery systems have great potential in the treatment of fungal infections in vivo[1].