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Ledipasvir D-tartrate

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Ledipasvir D-tartrate

Catalog No. T11832Cas No. 1502654-87-6

Ledipasvir D-tartrate with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. is an inhibitor of the hepatitis C virus NS5A.

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Product Introduction

Bioactivity

Description	Ledipasvir D-tartrate with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. is an inhibitor of the hepatitis C virus NS5A.
Targets&IC50	GT1a:（EC50）34 pM , GT1b: 4 pM
In vitro	Ledipasvir is highly protein-bound both in human serum and in the cell-culture medium (containing 10% BSA) of the replicon assay[1]. Ledipasvir exhibits an EC50 value of 141 nM against the JFH/3a-NS5A replicon[2].?Ledipasvir has GT1a and 1b EC50 values of 31 and 4 pM, respectively, and protein-adjusted EC50 values of 210 pM (GT1a) and 27 pM (GT1b) and the intrinsic EC50 of 39 is 310 fM for GT1a and 40 fM for GT1b.
In vivo	Ledipasvir exhibits favorable pharmacokinetics, including prolonged half-lives in plasma (rat 1.83 ± 0.22 hr, dog 2.63 ± 0.18 hr), low systemic clearance (CL), and moderate distribution volumes (Vss) surpassing total body water volume[1]. Its effectiveness is underscored by its high replicon potency, low clearance, commendable bioavailability, and extended half-lives across rat, dog, and monkey models, with a low predicted clearance in humans. The pharmacokinetic properties of Ledipasvir have been assessed in both rats and dogs.
Alias	GS-5885 D-tartrate

Chemical Properties

Molecular Weight	1039.104
Formula	C53H60F2N8O12
Cas No.	1502654-87-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 28 mg/mL (26.95 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9624 mL	4.8118 mL	9.6237 mL	48.1184 mL
5 mM	0.1925 mL	0.9624 mL	1.9247 mL	9.6237 mL
10 mM	0.0962 mL	0.4812 mL	0.9624 mL	4.8118 mL
20 mM	0.0481 mL	0.2406 mL	0.4812 mL	2.4059 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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