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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | Inquiry | Backorder | |
100 mg | Inquiry | Backorder |
Description | Ledipasvir D-tartrate with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. is an inhibitor of the hepatitis C virus NS5A. |
Targets&IC50 | GT1a:(EC50)34 pM , GT1b: 4 pM |
In vitro | Ledipasvir is highly protein-bound both in human serum and in the cell-culture medium (containing 10% BSA) of the replicon assay[1]. Ledipasvir exhibits an EC50 value of 141 nM against the JFH/3a-NS5A replicon[2].?Ledipasvir has GT1a and 1b EC50 values of 31 and 4 pM, respectively, and protein-adjusted EC50 values of 210 pM (GT1a) and 27 pM (GT1b) and the intrinsic EC50 of 39 is 310 fM for GT1a and 40 fM for GT1b. |
In vivo | Ledipasvir exhibits favorable pharmacokinetics, including prolonged half-lives in plasma (rat 1.83 ± 0.22 hr, dog 2.63 ± 0.18 hr), low systemic clearance (CL), and moderate distribution volumes (Vss) surpassing total body water volume[1]. Its effectiveness is underscored by its high replicon potency, low clearance, commendable bioavailability, and extended half-lives across rat, dog, and monkey models, with a low predicted clearance in humans. The pharmacokinetic properties of Ledipasvir have been assessed in both rats and dogs. |
Alias | GS-5885 D-tartrate |
Molecular Weight | 1039.104 |
Formula | C53H60F2N8O12 |
Cas No. | 1502654-87-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 28 mg/mL (26.95 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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