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Lesinurad sodium
🥰Excellent
Catalog No. T21301Cas No. 1151516-14-1
Alias RDEA-594 sodium, RDEA594 sodium, RDEA 594 sodium
Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.
Lesinurad sodium
🥰Excellent
Purity: 99.97%
Catalog No. T21301Alias RDEA-594 sodium, RDEA594 sodium, RDEA 594 sodiumCas No. 1151516-14-1
Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $31 | In Stock | |
| 5 mg | $47 | In Stock | |
| 10 mg | $67 | In Stock | |
| 25 mg | $134 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $52 | In Stock |
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Purity:99.97%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases. |
| Targets&IC50 | CYP2C8:16.2 μM, CYP2C9:14.4 μM, OAT1:0.85 µM (Km), OAT3:2 µM (Km) |
| In vitro | Lesinurad sodium is a novel selective uric acid reabsorption inhibitor (SURI). Lesinurad was found to be a substrate for the renal transporter proteins organic anion transporter protein (OAT1) and OAT3 with Mie constants (Km) of 0.85 µM and 2 µM, respectively.[1] Lesinurad sodium (RDEA594) acts as an inhibitor of URAT1 and OAT and promotes uric acid excretion in the proximal renal tubules. [2] Lesinurad sodium has the potential to be a uric acid-lowering drug by inhibiting uric acid reabsorption and has demonstrated excellent P450 metabolic properties, with IC50s of 14.4 μM for CYP2C9 and 16.2 μM for CYP2C8 and IC50s of more than 100 µM for CYP1A2, CYP2C19, and CYP2D6.[3] |
| In vivo | Lesinurad sodium demonstrated superior pharmacokinetic properties compared to its predecessor, RDEA806, with a 100 mg dose of Lesinurad sodium producing pharmacologic effects equivalent to a single dose of 300 mg to 800 mg of RDEA806.[3] The pharmacokinetics of Lesinurad sodium were similar to those of RDEA806, which was administered as a single dose of 100 mg. [3] |
| Alias | RDEA-594 sodium, RDEA594 sodium, RDEA 594 sodium |
| Molecular Weight | 426.26 |
| Formula | C17H13BrN3NaO2S |
| Cas No. | 1151516-14-1 |
| Smiles | O=C(CSC1=NN=C(N1C2=C3C=CC=CC3=C(C4CC4)C=C2)Br)[O-].[Na+] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (187.68 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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