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Lipoxin B4 methyl ester

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Catalog No. T38308Cas No. 97589-07-6

Lipoxin B4 (LXB4) methyl ester is a lipid-soluble prodrug form of the transcellular metabolite LXB4, which is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 of 0.3 nM.

Lipoxin B4 methyl ester

Lipoxin B4 methyl ester

😃Good
Catalog No. T38308Cas No. 97589-07-6
Lipoxin B4 (LXB4) methyl ester is a lipid-soluble prodrug form of the transcellular metabolite LXB4, which is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 of 0.3 nM.
Pack SizePriceAvailabilityQuantity
25 μg$685 35 days
50 μg$1,290 35 days
100 μg$2,450 35 days
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Product Introduction

Bioactivity
Description
Lipoxin B4 (LXB4) methyl ester is a lipid-soluble prodrug form of the transcellular metabolite LXB4, which is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 of 0.3 nM.
Chemical Properties
Molecular Weight366.498
FormulaC21H34O5
Cas No.97589-07-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
PBS (pH 7.2): 1 mg/mL (2.73 mM), Sonication is recommended.
Ethanol: 50 mg/mL (136.43 mM), Sonication is recommended.
DMF: 50 mg/mL (136.43 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/Ethanol/DMF
1mg5mg10mg50mg
1 mM2.7285 mL13.6426 mL27.2853 mL136.4264 mL
Ethanol/DMF
1mg5mg10mg50mg
5 mM0.5457 mL2.7285 mL5.4571 mL27.2853 mL
10 mM0.2729 mL1.3643 mL2.7285 mL13.6426 mL
20 mM0.1364 mL0.6821 mL1.3643 mL6.8213 mL
50 mM0.0546 mL0.2729 mL0.5457 mL2.7285 mL
100 mM0.0273 mL0.1364 mL0.2729 mL1.3643 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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