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LIT-001 free base

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Catalog No. T11856Cas No. 2245072-20-0

LIT-001 free base improves social interaction in a mouse model of autism. LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM).

LIT-001 free base
Other Forms of LIT-001 free base:
LIT-001T118572245072-21-1
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LIT-001 free base

😃Good
Catalog No. T11856Cas No. 2245072-20-0
LIT-001 free base improves social interaction in a mouse model of autism. LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM).
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Product Introduction

Bioactivity
Description
LIT-001 free base improves social interaction in a mouse model of autism. LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM).
In vitro
In the in vitro signal transduction experiments, LITL-001 free Base is an unbiased OT-R agonist that ACTS on the two main signal transduction pathways of the receptor and has a slight antagonistic effect on V1a and an agonist effect on V1b receptor, which is only observed at high concentration.
In vivo
LIT-001 free base (10-20 mg/kg; i.p.) alleviates core symptoms associated with autism spectrum disorders (ASD) [1].
Chemical Properties
Molecular Weight531.67
FormulaC28H33N7O2S
Cas No.2245072-20-0
Relative Density.1.33 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

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