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LOM612

Name: LOM612
Brand: TargetMol
SKU: T19405
Rating: 4.5 (1 reviews)

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Catalog No. T19405Cas No. 2173232-79-4

LOM612, a potent FOXO relocator, exhibits an EC50 of 1.5 μM in U2fox RELOC cells.

LOM612

😃Good

Catalog No. T19405Cas No. 2173232-79-4

LOM612, a potent FOXO relocator, exhibits an EC50 of 1.5 μM in U2fox RELOC cells.

Pack Size	Price	Availability
25 mg	$1,110	6-8 weeks
50 mg	$1,450	6-8 weeks
100 mg	$2,280	6-8 weeks
1 mL x 10 mM (in DMSO)	$318	6-8 weeks

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Product Introduction

Bioactivity

Description	LOM612, a potent FOXO relocator, exhibits an EC50 of 1.5 μM in U2fox RELOC cells.
Targets&IC50	FOXO:(EC50)1.5 μM
In vitro	LOM612 is cytotoxic to HepG2 cells, with an IC50 value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC50, 2.76 μM).LOM612 potently activates nuclear translocation of FOXO with an EC50 value of 1.5 μM, and this effect is independent of CRM-1.?LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL.?LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells.

Chemical Properties

Molecular Weight	258.3
Formula	C₁₃H₁₀N₂O₂S
Cas No.	2173232-79-4
Relative Density.	1.436 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 6 mg/mL (23.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8715 mL	19.3573 mL	38.7147 mL	193.5734 mL
5 mM	0.7743 mL	3.8715 mL	7.7429 mL	38.7147 mL
10 mM	0.3871 mL	1.9357 mL	3.8715 mL	19.3573 mL
20 mM	0.1936 mL	0.9679 mL	1.9357 mL	9.6787 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

LOM-612LOM612LOM 612FOXO