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LSN 3213128

Name: LSN 3213128
Brand: TargetMol
SKU: T11884
Price: 57 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T11884Cas No. 1941211-99-9

LSN 3213128, anti-tumor activity. is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells.

LSN 3213128

😃Good

Catalog No. T11884Cas No. 1941211-99-9

Pack Size	Price	Availability
25 mg	$1,430	6-8 weeks
50 mg	$1,860	6-8 weeks
100 mg	$2,500	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	LSN 3213128, anti-tumor activity. is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells.
Targets&IC50	AICARFT (cells):19 nM , AICARFT:16 nM

Chemical Properties

Molecular Weight	409.45
Formula	C₁₇H₁₆FN₃O₄S₂
Cas No.	1941211-99-9
Relative Density.	1.596 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 62.5 mg/mL (152.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4423 mL	12.2115 mL	24.4230 mL	122.1150 mL
5 mM	0.4885 mL	2.4423 mL	4.8846 mL	24.4230 mL
10 mM	0.2442 mL	1.2212 mL	2.4423 mL	12.2115 mL
20 mM	0.1221 mL	0.6106 mL	1.2212 mL	6.1058 mL
50 mM	0.0488 mL	0.2442 mL	0.4885 mL	2.4423 mL
100 mM	0.0244 mL	0.1221 mL	0.2442 mL	1.2212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

LSN-3213128LSN 3213128LSN3213128