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LSN3106729 hydrochloride

Name: LSN3106729 hydrochloride
Brand: TargetMol
SKU: T36967
Price: 50 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T36967Cas No. 2704316-82-3

LSN3106729 hydrochloride, the metabolite of Abemaciclib , is a CDK inhibitor with antitumor activity. LSN3106729 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1].

LSN3106729 hydrochloride

Catalog No. T36967Cas No. 2704316-82-3

LSN3106729 hydrochloride, the metabolite of Abemaciclib , is a CDK inhibitor with antitumor activity. LSN3106729 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1].

Pack Size	Price	Availability
5 mg	$291	Backorder
10 mg	$456	Backorder
25 mg	$822	Backorder
50 mg	$1,360	Backorder
100 mg	$1,860	Backorder
1 mL x 10 mM (in DMSO)	$339	Backorder

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Product Introduction

Bioactivity

Description

LSN3106729 hydrochloride, the metabolite of Abemaciclib , is a CDK inhibitor with antitumor activity. LSN3106729 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1].
[1]. Edward S. Kim, et al. Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non-Small Cell Lung Cancer: A Phase Ib Study. [2]. Nathanael Gray, et al. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use. WO2017185031A1.

Chemical Properties

Molecular Weight	531.00
Formula	C₂₅H₂₉ClF₂N₈O
Cas No.	2704316-82-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (235.40 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8832 mL	9.4162 mL	18.8324 mL	94.1620 mL
5 mM	0.3766 mL	1.8832 mL	3.7665 mL	18.8324 mL
10 mM	0.1883 mL	0.9416 mL	1.8832 mL	9.4162 mL
20 mM	0.0942 mL	0.4708 mL	0.9416 mL	4.7081 mL
50 mM	0.0377 mL	0.1883 mL	0.3766 mL	1.8832 mL
100 mM	0.0188 mL	0.0942 mL	0.1883 mL	0.9416 mL

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

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