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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $291 | Backorder | |
10 mg | $456 | Backorder | |
25 mg | $822 | Backorder | |
50 mg | $1,360 | Backorder | |
100 mg | $1,860 | Backorder | |
1 mL x 10 mM (in DMSO) | $339 | Backorder |
Description | LSN3106729 hydrochloride, the metabolite of Abemaciclib , is a CDK inhibitor with antitumor activity. LSN3106729 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1]. [1]. Edward S. Kim, et al. Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non-Small Cell Lung Cancer: A Phase Ib Study. [2]. Nathanael Gray, et al. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use. WO2017185031A1. |
Molecular Weight | 531.00 |
Formula | C25H29ClF2N8O |
Cas No. | 2704316-82-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (235.40 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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