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Lumasiran sodium
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Catalog No. T39274Cas No. 1834612-06-4
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, targets glycolate oxidase to reduce hepatic oxalate production and urinary oxalate excretion, showing promise in addressing the underlying cause of progressive kidney failure in individuals with primary hyperoxaluria type 1 (PH1).
Lumasiran sodium
😃Good
Catalog No. T39274Cas No. 1834612-06-4
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, targets glycolate oxidase to reduce hepatic oxalate production and urinary oxalate excretion, showing promise in addressing the underlying cause of progressive kidney failure in individuals with primary hyperoxaluria type 1 (PH1).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | 1.444 € | Backorder |
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Chemical Properties
| Description | Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, targets glycolate oxidase to reduce hepatic oxalate production and urinary oxalate excretion, showing promise in addressing the underlying cause of progressive kidney failure in individuals with primary hyperoxaluria type 1 (PH1). |
| In vitro | Lumasiran sodium is utilized in the study of Primary Hyperoxaluria Type 1 (PH1). It functions by silencing the gene responsible for glycolate oxidase production, subsequently reducing glycolate oxidase levels. This inhibition blocks oxalate synthesis, the harmful metabolite linked to PH1's clinical symptoms[1]. |
| In vivo | Lumasiran sodium is a liver-targeted therapeutic agent administered subcutaneously, functioning through RNA interference (RNAi) [2]. |
| Cas No. | 1834612-06-4 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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