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Luvixasertib hydrochloride

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Catalog No. T84711Cas No. 1610677-37-6
Alias CFI-402257 hydrochloride

CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].

Luvixasertib hydrochloride

Luvixasertib hydrochloride

😃Good
Catalog No. T84711Alias CFI-402257 hydrochlorideCas No. 1610677-37-6
CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].
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50 mgInquiry8-10 weeks
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Product Introduction

Bioactivity
Description
CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].
In vitro
CFI-402257 exhibits high specificity towards TTK, showing no inhibitory activity against a broad range of 262 human kinases at a concentration of 1 μM. It is a potent inhibitor of cell growth, as evidenced in various studies. At a concentration of 200 nM for 6 hours, it significantly increases chromosome missegregations. Furthermore, it induces a dose-dependent disruption of the cell cycle at concentrations of 0, 50, or 100 nM, increasing the prevalence of aneuploid DNA content in cells. These effects align with those expected from Mps1 kinase inhibition, such as SAC inactivation, leading to chromosome missegregation, aneuploidy, and ultimately, cell death.
AliasCFI-402257 hydrochloride
Chemical Properties
Molecular Weight535.04
FormulaC28H31ClN6O3
Cas No.1610677-37-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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