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LY 254155

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Catalog No. T11922Cas No. 135503-67-2

LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.

LY 254155

LY 254155

😃Good
Catalog No. T11922Cas No. 135503-67-2
LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.
Pack SizePriceAvailabilityQuantity
25 mg$2,57010-14 weeks
50 mg$3,38010-14 weeks
100 mg$4,60010-14 weeks
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Product Introduction

Bioactivity
Description
LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.
Targets&IC50
mFBP:1.7± 0.1 nM (ki), GARFT (human):ki: 2.1±0.2
In vitro
LY 254155 ?binds to membrane folate-binding protein (mFBP) [1] and inhibits recombinant human monofunctional glycinamide ribonucleotide formyltransferase (hGARFT).
In vivo
LY 254155, administered at doses of 5, 10, 20, and 40 mg/kg, effectively suppresses the growth of C3H carcinoma in C3H mice, achieving tumor growth inhibition rates of 49%, 71%, 90%, and 94%, respectively[1]. Furthermore, LY 254155 demonstrates efficacy across a wide range of both murine and human xenograft solid tumors, indicating its broad-spectrum antitumor activity.
Chemical Properties
Molecular Weight449.48
FormulaC19H23N5O6S
Cas No.135503-67-2
Relative Density.1.68 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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