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LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,570 | 10-14 weeks | |
50 mg | $3,380 | 10-14 weeks | |
100 mg | $4,600 | 10-14 weeks |
Description | LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively. |
Targets&IC50 | mFBP:1.7± 0.1 nM (ki), GARFT (human):ki: 2.1±0.2 |
In vitro | LY 254155 ?binds to membrane folate-binding protein (mFBP) [1] and inhibits recombinant human monofunctional glycinamide ribonucleotide formyltransferase (hGARFT). |
In vivo | LY 254155, administered at doses of 5, 10, 20, and 40 mg/kg, effectively suppresses the growth of C3H carcinoma in C3H mice, achieving tumor growth inhibition rates of 49%, 71%, 90%, and 94%, respectively[1]. Furthermore, LY 254155 demonstrates efficacy across a wide range of both murine and human xenograft solid tumors, indicating its broad-spectrum antitumor activity. |
Molecular Weight | 449.48 |
Formula | C19H23N5O6S |
Cas No. | 135503-67-2 |
Relative Density. | 1.68 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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