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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,070 | 6-8 weeks | |
50 mg | $1,390 | 6-8 weeks | |
100 mg | $2,090 | 6-8 weeks |
Description | LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.13 μM for Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS) and 0.015 μM for Plasmodium falciparum lysyl-tRNA synthetase (PfKRS). |
Targets&IC50 | PfKRS:0.015 μM , CpKRS:0.13 μM |
In vitro | LysRs-IN-2 is active against whole-cell bloodstream P. falciparum 3D7 (EC50=0.27 μM), HepG2 cells (EC50=49 μM), HsKRS (IC50=1.8 μM), and Cryptosporidium parvum (EC50=2.5 μM) [1]. |
In vivo | LysRs-IN-2 (20 mg/kg; orally once a day for 7 days) reduces parasite shedding in NOD SCID gamma mice and INF-γ-knockout mice (Cryptosporidium mouse models)[1].LysRs-IN-2 (1.5 mg/kg; orally once a day for 4 days) reduces parasitemia by 90% in the murine P. falciparum SCID model. |
Molecular Weight | 355.31 |
Formula | C17H16F3NO4 |
Cas No. | 2170696-76-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (168.87 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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