Mab Aspartate Decarboxylase-IN-1 is a potent inhibitor of aspartate decarboxylase (PanD) with an IC50 of 56.3 μM and exhibits antibacterial activity [1].

Mab Aspartate Decarboxylase-IN-1 (compound analogue 2) effectively inhibits Mab PanDE119A, Mab PanDS135A, and Mab PanDY126A mutants with rates of 70.5%, 74.4%, and 81.8%, respectively [1]. At 0-200 μM, it inhibits the Mycobacterium abscessus (Mab) PanD enzyme, converting l-Aspartate to β-Alanine, with an IC50 of 56.3±4.8 μM [1]. At 0-4 mM concentrations, it exhibits antibacterial activity against various M. abscessus subspecies, specifically an IC50 of 0.7 mM for M. abscessus subsp. abscessus ATCC 19977, and IC50 values of 1-2 mM for M. abscessus subsp. bolletii CCUG 50184T, M. abscessus subsp. massiliense CCUG 48898T, M. abscessus subsp. abscessus Bamboo, and M. abscessus subsp. abscessus ATCC 19977 [1]. The compound’s interaction with the target enzyme is primarily through electrostatic and hydrogen bonding [1].