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Macrophage-activating lipopeptide 2
Catalog No. TP2791Cas No. 250718-44-6
Alias MALP-2
Macrophage-activating lipopeptide 2 (MALP-2) is a lipopeptide that acts as an agonist for Toll-like receptors TLR-2 and TLR-6. It enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, thereby improving vasodilation. Additionally, MALP-2 increases the adhesion of leukocytes to the endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL).
Macrophage-activating lipopeptide 2
Catalog No. TP2791Alias MALP-2Cas No. 250718-44-6
Macrophage-activating lipopeptide 2 (MALP-2) is a lipopeptide that acts as an agonist for Toll-like receptors TLR-2 and TLR-6. It enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, thereby improving vasodilation. Additionally, MALP-2 increases the adhesion of leukocytes to the endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL).
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Chemical Properties
| Description | Macrophage-activating lipopeptide 2 (MALP-2) is a lipopeptide that acts as an agonist for Toll-like receptors TLR-2 and TLR-6. It enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, thereby improving vasodilation. Additionally, MALP-2 increases the adhesion of leukocytes to the endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL). |
| In vitro | Macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) enhances the expression of primary endothelial adhesion molecules and leukocyte integrin receptors, thereby improving leukocyte endothelial adhesion. Additionally, Macrophage-activating lipopeptide 2 (1 µg/mL, 2 h) promotes the phosphorylation of Protein Kinase B and eNOS in endothelial MyEnd cells, facilitating the release of nitric oxide (NO). |
| In vivo | Macrophage-activating lipopeptide 2 (1 µg dissolved in 125 µL PBS; administered daily; for 10 days; via intravenous injection) enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe knockout mice subjected to experimental femoral artery ligation (FAL). |
| Alias | MALP-2 |
| Molecular Weight | 2135.56 |
| Formula | C99H167N19O30S |
| Cas No. | 250718-44-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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