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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | MAIT-203, a cyclopentyalanin-derived peptidomimetic, effectively disrupts the interaction between adenomatous polyposis coli (APC) and Asef (RhoGEF4), without affecting APC-Sam68 or APC-striatin interactions. It binds to APC-ARM domains with a K i of 0.015 μM and a K d of 0.036 μM, and notably inhibits the migration and invasion of colorectal cancer cells. |
In vitro | MAIT-203 at concentrations of 10 μM and 25 μM significantly attenuates the interaction between Asef and APC in HEK293T cells, demonstrating a dose-dependent effect over a 24-hour period [1]. |
Cas No. |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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