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MAK683-CH2CH2COOH

Name: MAK683-CH2CH2COOH
Brand: TargetMol
SKU: T13765
Rating: 4.5 (1 reviews)

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Catalog No. T13765Cas No. 2639882-68-9

MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein) and, together with a VHL ligand for the E3 ubiquitin ligase, has been used to design EED-Targeted PROTACs, specifically EED degrader-1 and PROTAC EED degrader-2 [1].

MAK683-CH2CH2COOH

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Catalog No. T13765Cas No. 2639882-68-9

Pack Size	Price	Availability
25 mg	$1,517	8-10 weeks
50 mg	$2,388	8-10 weeks
100 mg	$3,785	8-10 weeks

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Product Introduction

Bioactivity

Description	MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein) and, together with a VHL ligand for the E3 ubiquitin ligase, has been used to design EED-Targeted PROTACs, specifically EED degrader-1 and PROTAC EED degrader-2 [1].
In vitro	With 14 days treatment, MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI 50 of 14 nM [1].

Chemical Properties

Molecular Weight	448.45
Formula	C₂₃H₂₁FN₆O₃
Cas No.	2639882-68-9
Relative Density.	1.50 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

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