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Mapracorat

Name: Mapracorat
Brand: TargetMol
SKU: T13451L
Rating: 4.5 (1 reviews)

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Catalog No. T13451LCas No. 887375-26-0

Alias ZK-245186, BOL-303242X

Mapracorat is a novel, non-steroidal, selective agonist of the glucocorticoid receptor (GR).

Mapracorat

🥰Excellent

Catalog No. T13451LAlias ZK-245186, BOL-303242XCas No. 887375-26-0

Mapracorat is a novel, non-steroidal, selective agonist of the glucocorticoid receptor (GR).

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Product Introduction

Bioactivity

Description	Mapracorat is a novel, non-steroidal, selective agonist of the glucocorticoid receptor (GR).
In vitro	Mapracorat concentration-dependently inhibited TNFα secretion from activated canine PBMC (IC50: approximately 0.2 nM).
In vivo	Intradermal injection of compound 48/80 (50 μg in 50 μL saline) induced a pronounced wheal and flare reaction within 60 minutes. Compared to vehicle (acetone)-treated areas, topical pre-treatment with mapracorat (0.1%) significantly reduced these wheal and flare responses.
Alias	ZK-245186, BOL-303242X

Chemical Properties

Molecular Weight	462.48
Formula	C₂₅H₂₆F₄N₂O₂
Cas No.	887375-26-0
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 33.6 mg/mL (72.65 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1623 mL	10.8113 mL	21.6226 mL	108.1128 mL
5 mM	0.4325 mL	2.1623 mL	4.3245 mL	21.6226 mL
10 mM	0.2162 mL	1.0811 mL	2.1623 mL	10.8113 mL
20 mM	0.1081 mL	0.5406 mL	1.0811 mL	5.4056 mL
50 mM	0.0432 mL	0.2162 mL	0.4325 mL	2.1623 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ZK 245186MapracoratZK245186