MARK-IN-2

MARK-IN-2 is a potent inhibitor of microtubule affinity-regulating kinase (MARK) with an IC50 of 5 nM.

Catalog No. T11946Cas No. 1314893-26-9

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MARK-IN-2

Catalog No. T11946Cas No. 1314893-26-9

MARK-IN-2 is a potent inhibitor of microtubule affinity-regulating kinase (MARK) with an IC50 of 5 nM.

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Pack Size	Price	Availability
25 mg	$2,120	8-10 weeks
50 mg	$2,780	8-10 weeks
100 mg	$3,700	8-10 weeks

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Product Introduction

Bioactivity

Description	MARK-IN-2 is a potent inhibitor of microtubule affinity-regulating kinase (MARK) with an IC50 of 5 nM.
Targets&IC50	MARK:5 nM
In vitro	MARK-IN-2 inhibits MARK3 with an IC50 of 5 nM. MARK-IN-2 also inhibits MARK3 in primary cell culture of rat cortical neurons with an IC50 of 280 nM.MARK-IN-2 is a potent MARK inhibitor.?Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease.
In vivo	MARK-IN-2 has moderate terminal elimination half-life (t1/2=0.7 h, and 1 h for rat and dog) .Characterization of the i.v. pharmacokinetic properties of MARK-IN-2 in rat and dog reveals reasonable volumes of distribution but moderate to high clearance and short half-lives.

Chemical Properties

Molecular Weight	425.88
Formula	C₁₈H₁₈ClF₂N₅OS
Cas No.	1314893-26-9

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Keywords

MARK IN 2MARK-IN-2MARKIN2