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MEL24

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Catalog No. T78166Cas No. 642072-48-8

MEL24, an Mdm2 E3 ligase inhibitor, diminishes cell viability and enhances sensitivity to DNA-damaging agents in a p53-dependent manner, suggesting its potential for in vitro antitumor research [1].

MEL24

MEL24

😃Good
Catalog No. T78166Cas No. 642072-48-8
MEL24, an Mdm2 E3 ligase inhibitor, diminishes cell viability and enhances sensitivity to DNA-damaging agents in a p53-dependent manner, suggesting its potential for in vitro antitumor research [1].
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5 mgInquiry8-10 weeks
50 mgInquiry8-10 weeks
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Product Introduction

Bioactivity
Description
MEL24, an Mdm2 E3 ligase inhibitor, diminishes cell viability and enhances sensitivity to DNA-damaging agents in a p53-dependent manner, suggesting its potential for in vitro antitumor research [1].
In vitro
MEL24 targets 293T cells with an ED50 of 9.2 μM [1]. At a concentration of 15 μM for 6 hours, MEL24 elevates the levels of Mdm2, p53, and MdmX, activating p53, and inhibiting the degradation of endogenous MdmX in HCT116 cells (p53 wild-type) [1].
Chemical Properties
Molecular Weight326.35
FormulaC17H18N4O3
Cas No.642072-48-8
Storage & Solubility Information
StorageShipping with blue ice.

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