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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $378 | 7-10 days |
Description | Melflufen (Melphalan flufenamide) hydrochloride, an alkylating agent and dipeptide prodrug of Melphalan, exhibits antitumor activity by inducing irreversible DNA damage and cytotoxicity in multiple myeloma (MM) cells, while also inhibiting angiogenesis. |
In vitro | Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM; 24 hours) significantly reduces the viability of multiple myeloma cells (MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, ANBL-6) in a concentration-dependent manner, induces apoptosis in MM.1S cells, and potently activates exosome secretion[1][3]. |
In vivo | Melflufen (Melphalan flufenamide) hydrochloride, administered intravenously at a dosage of 3 mg/kg twice weekly for two weeks, demonstrates significant anti-multiple myeloma (MM) activity in a human plasmacytoma MM.1S xenograft mouse model using CB-17 SCID mice. This treatment notably inhibited MM tumor growth and extended the survival of the mice. |
Alias | Melflufen hydrochloride, Melphalan flufenamide hydrochloride |
Molecular Weight | 534.88 |
Formula | C24H31Cl3FN3O3 |
Cas No. | 380449-54-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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