Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | Inquiry | Backorder | |
100 mg | Inquiry | Backorder | |
500 mg | Inquiry | Backorder |
Description | Methyl α-Linolenyl Fluorophosphonate is an inhibitor of phospholipases. Methyl α-Linolenyl Fluorophosphonate (MLnFP), an analog of methyl Arachidonyl Fuorophosphonate (MAFP), has not been completely investigated for its pharmacological activity. |
In vitro | In vitro: MethylArachidonyl Fluorophosphonate (MAFP) was reported to be a selective, active-site directed, irreversible inhibitor of cytosolic phospholipase A2 (cPLA2). MAFP could also potently inhibit the Ca2+-independent cytosolic phospholipase A2 (iPLA2) in a concentration-dependent manner. Such inhibition was not reversed upon extensive dilution of the enzyme into the assay mixture. The Preincubation of iPLA2 with MAFP led to a linear and time-dependent inactivation of enzyme activity, and the enzyme was protected from inactivation by the reversible inhibitor. The ability of MAFP to inhibit the iPLA 2 indicated that this enzyme proceeded via an acyl-enzyme intermediate. Further testing showed that MAFP could not inhibit the CoA-dependent acyltransferase, arachidonoyI-CoA synthetase, or CoA-independent transacylase activities. Therefore, MAFP was not a general inhibitor for enzymes acting on arachidonoyi substrates [1]. |
Molecular Weight | 344.4 |
Formula | C19H34FO2P |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | Ethanol: ≤5 mg/mL DMSO: 5 mg/mL |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.