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MGAT2-IN-1

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MGAT2-IN-1

Catalog No. T12028Cas No. 1800025-30-2

MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).

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Pack Size	Price	Availability
5 mg	$469	10-14 weeks
25 mg	$1,670	10-14 weeks
50 mg	$2,180	10-14 weeks
100 mg	$3,480	10-14 weeks
1 mL x 10 mM (in DMSO)	$739	10-14 weeks

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Product Introduction

Bioactivity

Description	MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).
In vivo	In the lipid utilization analysis, MGAT2-IN-1 significantly increases free fatty acid (FFA) and acylcarnitine levels. MGAT2-IN-1 (30 mg/kg) also significantly reduces food intake dose dependently, suppresses BW gains. MGAT2-IN-1 shows anti-diabetic effects in mice[1].

Chemical Properties

Molecular Weight	654.01
Formula	C27H21ClF5N7O3S
Cas No.	1800025-30-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (191.13 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5290 mL	7.6451 mL	15.2903 mL	76.4514 mL
5 mM	0.3058 mL	1.5290 mL	3.0581 mL	15.2903 mL
10 mM	0.1529 mL	0.7645 mL	1.5290 mL	7.6451 mL
20 mM	0.0765 mL	0.3823 mL	0.7645 mL	3.8226 mL
50 mM	0.0306 mL	0.1529 mL	0.3058 mL	1.5290 mL
100 mM	0.0153 mL	0.0765 mL	0.1529 mL	0.7645 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MGAT2 IN 1MGAT2-IN-1MGAT-2-IN-1MGAT2IN1