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MitoPBN is a mitochondria-targeted antioxidant that accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect blocked by the addition of the mitochondrial membrane potential uncoupler FCCP. MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 at a concentration of 250 nM in vitro, but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $1,050 | 35 days |
Description | MitoPBN is a mitochondria-targeted antioxidant that accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect blocked by the addition of the mitochondrial membrane potential uncoupler FCCP. MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 at a concentration of 250 nM in vitro, but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria. |
Molecular Weight | 590.542 |
Formula | C33H37BrNO2P |
Cas No. | 652968-37-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMF:PBS(pH7.2) (1:2): 0.33 mg/mL DMF: 25 mg/mL DMSO: 1 mg/mL Ethanol: 0.33 mg/mL |
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